REV-ERB-BETA-2, A NOVEL ISOFORM OF THE REV-ERB FAMILY OF ORPHAN NUCLEAR RECEPTORS

We have isolated a rat complementary DNA clone corresponding to a nove l isoform of the hormone nuclear receptor superfamily. This clone enco des a 383 amino acid residue protein designated as Rev-erb beta 2. Thi s protein is identical until residue 382 to the Rev-erb beta 1 protein , which is 195 amino acids longer. Several arguments pointed out that the Rev-erb beta 2 cDNA may originate from the same gene as Rev-erb be ta 1 by alternative splicing and using a different polyadenylation sit e. Our results indicate that Rev-erb beta 2 is a new isoform of the Re v-erb family of orphan nuclear receptors.