SYNTHESIS AND PHARMACOLOGICAL STUDY OF NEW 3,4-DIHYDRO-2H,6H-PYRIMIDO[2,1-B][1,3]THIAZINES

Authors
BOZSING D SOHAR P GIGLER G KOVACS G
Citation
D. Bozsing et al., SYNTHESIS AND PHARMACOLOGICAL STUDY OF NEW 3,4-DIHYDRO-2H,6H-PYRIMIDO[2,1-B][1,3]THIAZINES, European journal of medicinal chemistry, 31(9), 1996, pp. 663-668
Citations number
9
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
31
Issue
9
Year of publication
1996
Pages
663 - 668
Database
ISI
SICI code
0223-5234(1996)31:9<663:SAPSON>2.0.ZU;2-R
Abstract
A series of racemic pyrimido-thiazine derivatives was synthesized and many of their in vivo activities found to be comparable to acetylsalic ylic acid and aminophenazone in an antiinflammatory model and an antip yretic test. Analogues 7a and 7e are the most potent in rat carrageeni n and yeast fever assays. These compounds did not inhibit prostaglandi n biosynthesis in vitro.