P. Heinonen et al., SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF )-(2-ETHYL-2,3-DIHYDRO-2-SILAINDEN-2-YL)IMIDAZOLE, A SILICON ANALOG OF ATIPAMEZOLE, European journal of medicinal chemistry, 31(9), 1996, pp. 725-729
5)-(2-Ethyl-2,3-dihydro-2-silainden-2-yl)imidazole 2a, )-(2-methyl-2,3
-dihydro-2-silainden-2-yl)imidazole 2b and yl-2,3-dihydro-2-silainden-
2-yl)-2-methylimidazole 2c, C2 silicon analogues of the commercially a
vailable alpha(2)-adrenergic receptor antagonist atipamezole 1, were p
repared and their pharmacological properties were evaluated. The resul
ts show that 2a retained significant affinity for the receptors, and t
he in vivo pharmacokinetic properties of 2a were comparable to those o
f 1.