Eight total hip and two total knee arthroplasties were performed from
1986 to 1991 in eight patients who had orthotopic liver transplantatio
n. The indications for joint arthroplasty were avascular necrosis of t
he femoral head in five hips, pathologic femoral neck fracture caused
by osteopenia in three hips, avascular necrosis of femoral and tibial
condyles in one knee, and posttraumatic arthritis in one knee. Six pat
ients (75%) had significant osteopenia. The mean interval between live
r transplantation surgery and hip or knee joint arthroplasty was 2 yea
rs (8-48 months). The patients who had hip arthroplasty were followed
for a mean of 4.85 years (2-8 years), and those who bad a knee arthrop
lasty after a hip arthroplasty, for a mean of 3.5 years (2-5 years) af
ter the knee arthroplasty. In the patients who had hip arthroplasty, t
he mean Harris hip score was improved from 34 to 82 points. In the two
patients who had a knee arthroplasty, the mean score was improved to
100 points both for pain and function of the knee and for overall func
tion from mean preoperative knee scores of 49 and 25 points, respectiv
ely. Radiographs did not reveal any loosening of the components. None
of the patients required reoperation, and there were no serious postop
erative complications.