LYMPHOCYTE SUBSET DIVERSITY IN IDIOPATHIC CD4(-LYMPHOCYTOPENIA() T)

The clinical and public health importance of CD4(+) T lymphocytopenia without human immunodeficiency virus infection is still unclear. We de scribe herein two new human immunodeficiency virus-negative patients w ith low numbers of peripheral CD4(+) T cells and opportunistic infecti ons (cerebral toxoplasmosis and tuberculosis plus extrapulmonary histo plasmosis). The low numbers of CD4(+) CD29(+) memory cells, the high p ercentage of gamma delta T-cell receptor cells, and the recovery of CD 4(+) I-ells after treatment were remarkable.