Ss. Almeida et al., MALNUTRITION AND REACTIVITY TO DRUGS ACTING IN THE CENTRAL-NERVOUS-SYSTEM, Neuroscience and biobehavioral reviews, 20(3), 1996, pp. 389-402
There is a well-established body of data demonstrating that protein or
protein-calorie malnutrition experienced early in life is associated
with neuroanatomical, neurochemical, as well as behavioral alterations
in both animals and humans. A number of studies has focused on the fo
llowing question: are the neuroanatomical and/or neurochemical changes
produced by early malnutrition responsible for the altered behaviors
reported in malnourished animals? A tool that has been used to help an
swer this question is the administration of drugs with specific action
s in the various neurotransmitter systems in the central nervous syste
m (CNS). This neuropharmacological approach has produced a considerabl
e amount of data demonstrating that malnourished animals react to drug
s differently from controls, suggesting that the altered behavioral ex
pression of these animals could be partly explained by the alterations
in the brain function following malnutrition. The present review will
provide an overview of the literature investigating the reactivity of
malnourished animals to psychoactive drugs acting through GABAergic,
catecholaminergic, serotonergic, opioid and cholinergic neurotransmitt
er systems. Altered responsiveness to psychoactive drugs in malnourish
ed animals may be especially relevant to understanding the consequence
s of malnutrition in human populations. Copyright (C) 1996 Elsevier Sc
ience Ltd.