M. Uchiyama et al., INTESTINAL MOTILITY AFTER MASSIVE SMALL-BOWEL RESECTION IN CONSCIOUS CANINES - COMPARISON OF ACUTE AND CHRONIC PHASES, Journal of pediatric gastroenterology and nutrition, 23(3), 1996, pp. 217-223
To evaluate intestinal function after 80% massive distal small bowel r
esection (MSBR), we continuously monitored interdigestive and postpran
dial bowel motility using bipolar electrodes and/or contractile strain
gauge force transducers in conscious beagle dogs before and at 2-4 we
eks (acute postoperative phase; acute phase) and 8-13 months (chronic
postoperative phase; chronic phase) after the surgery. Fasting duodena
l migrating myoelectric (or motor) complexes (MMC) occurred at longer
intervals in the acute phase after 80% MSBR than in control beagles. I
ntervals between duodenal MMC in the chronic phase were similar to tho
se found in control beagles. MMC arising from the duodenum were often
interrupted before the jejunum above the anastomosis in the acute phas
e, and a slight recovery of propagation frequency to the jejunum above
the anastomosis was observed in the chronic phase. However, duodenal
MMC did not migrate smoothly to the terminal ileum in both groups. In
the acute phase, the velocity of duodenal MMC propagation was slowed i
n every intestinal segment, including the duodenum and the jejunum abo
ve the anastomosis, and had not recovered even long after the operatio
n. The duration of the postprandial period without duodenal MMC was pr
olonged significantly in the acute phase postoperatively. Although it
shortened in the chronic phase, it still remained significantly longer
than in controls. These findings suggest that changes in gut motility
after MSBR tend to compensate for the shorter intestine and maintain
small bowel absorption early postoperatively. However, these compensat
ory changes decrease over the long term, and their adaptive contributi
ons to increased intestinal absorption may decrease as well.