DUMPING SYNDROME FOLLOWING NISSEN FUNDOPLICATION, DIAGNOSIS, AND TREATMENT

We evaluated the prevalence, diagnosis, and treatment of dumping syndr ome (DS) following Nissen fundoplication in 50 consecutive infants and children who underwent the operation for gastroesophageal reflux. Exa mination included a preoperative dietary assessment with emphasis on s pecific postprandial clinical symptoms and technetium scintigraphy to evaluate gastric emptying. In the immediate postoperative period, post prandial glucose levels were examined in all patients with symptoms cl inically suggestive of DS. In the late postoperative period (6 months to 5.5 years), all patients with more than one specific clinical sympt om of DS were further evaluated by glucose tolerance test (GTT), HbA(1 )C levels, and gastric technetium scintigraphy. DS was diagnosed in 15 patients (30%). Five patients had immediate severe DS (SDS), and 10 i n the late postoperative course had latent postoperative DS (LDS). In all patients with DS, preoperative and postoperative gastric emptying scan T 1/2 did not show any statistical significance. High levels of H bA(1)C ranging from 7.9 to 9% (mean, 8.25 +/- 0.5) were found in only three patients. Treatment included parenteral nutrition in one patient . All the others were successfully managed with nutritional manipulati on alone, using a combination of lactose-free formula and fat emulsion . In patients whose postprandial symptoms persisted, pectin 5-15 g/day divided into six doses was added to the diet. Following 6 months of d ietary treatment, the postprandial normoglycomic response was restored . Eleven patients experienced complete resolution of symptoms (78.5%), and three patients (21.4%) showed significant clinical improvement. T his study indicates that DS is a common complication following Nissen fundoplication. The GTT is the most reliable examination for establish ing the diagnosis. Treatment is simple and effective. The technetium g astric emptying scan and HbA(1)C level do not play a significant role in the diagnosis.