Objective: To review the literature on the association of exercise and
rehabilitation among cancer patients in order to stimulate research i
n this field. Data Sources: Computerized literature search of database
s (Medline, Psychlit, Sportdiscus, Cinahl) and manual search of journa
ls done to identify all empirical studies on exercise and rehabilitati
on of cancer patients ever conducted and published in any language on
this topic. Study Selection: Eleven studies found, of these, two were
unpublished conference proceedings and could not be obtained, two were
doctoral dissertations and seven were published research studies. Of
the nine studies reviewed, four were randomized controlled trials, thr
ee were quasi-experimental studies, and two were retrospective studies
(case-control and cohort in design). All of the studies examined brea
st cancer patients only. Data Extraction: Qualitative review conducted
since the studies had heterogeneous study designs including the type
and form of exercise intervention or measurement, the data collection
methods, and the outcome variables. Data Synthesis: Overall, exercise
resulted in an improvement of the physiologic parameters observed, inc
luding increases in functional capacity and lean tissue, decreases in
percent body fat, nausea and fatigue. Improvements in psychologic indi
cators of well-being and quality of life also found. Conclusions: Exer
cise appears to improve breast cancer patients' physiologic and psycho
logic well being; however, the research studies reviewed here have num
erous methodologic limitations and these results must be considered as
preliminary evidence only. To improve knowledge of how exercise may h
elp the rehabilitation of all types of cancer patients, future researc
h studies are needed that use a wider sample of cancer patients, a wel
l-designed randomized controlled design, an exercise intervention that
more closely reflects true life circumstances, that is of long durati
on, that measures numerous physiologic and psychologic changes, and th
at examines exercise recruitment and adherence problems that may occur
.