AUP1, A NOVEL GENE ON MOUSE CHROMOSOME-6 AND HUMAN-CHROMOSOME 2P13

We have cloned a novel mouse cDNA, Aup1, encoding a predicted protein of 410 amino acid residues. The 1.5-kb Aup1 transcript is ubiquitously expressed in mouse tissues, An evolutionary relationship to the Caeno rhabditis elegans predicted protein F44b9.5 is indicated by the 35% id entity and 53% conservation of the amino acid sequences. Nineteen rela ted human ESTs spanning 80% of the protein have also been identified, with a predicted amino acid sequence identity of 86% between the human and the mouse proteins. The gene has been mapped to a conserved linka ge group on human chromosome 2p13 and mouse Chromosome 6. Aup1 was eli minated as a candidate gene for two closely linked disorders, human LG MD2B and mouse mnd2. (C) 1996 Academic Press, Inc.