AN ATTENUATED BOVINE HERPESVIRUS-1 MARKER VACCINE INDUCES A BETTER PROTECTION THAN 2 INACTIVATED MARKER VACCINES

A comparative study on the efficacy of 3 bovine herpesvirus 1 (BHV1) m arker vaccines was carried out. An attenuated gE-negative vaccine, an inactivated gE-negative vaccine and an experimental gD-subunit vaccine were tested twice in a vaccination-challenge experiment in cattle. Th e attenuated vaccine induced the best clinical protection as evidenced by the total absence of clinical signs and fever in cattle. In additi on, the attenuated vaccine reduced the shedding of challenge virus sig nificantly more than the inactivated vaccines. Of the inactivated vacc ines, the gE-negative vaccine induced a better clinical protection tha n the gD-subunit vaccine.