Kb. Johnson et al., THE EFFECT OF HYPOTHERMIA ON POTASSIUM AND GLUCOSE CHANGES IN ISOBARIC HEMORRHAGIC-SHOCK IN THE RAT, Shock, 6(3), 1996, pp. 223-229
Hypothermia has been shown to decrease oxygen consumption requirements
and improve survival during hemorrhagic shock. However, hypothermia a
pplied therapeutically does not prevent the development of a lactic ac
idosis during hemorrhage, We re-examined the development of a hemorrha
ge-induced lactic acidosis and other metabolic parameters (glucose, pl
asma electrolytes, and arterial blood gases) at various temperatures (
29-37 degrees C) to better define the protective action of hypothermia
in hemorrhagic shock, Five groups of male, Sprague-Dawley rats were b
led to a mean arterial blood pressure (MABP) of 40 mmHg over a 15 min
period and held there by further blood removal until death, The final
level and rate of development of the lactic acidemia was the same in a
ll groups, However, the rate of decline in plasma glucose and rate of
rise in plasma potassium were temperature dependent. These results sug
gest that temperature-dependent changes in serum glucose and potassium
may contribute to the protective effect of hypothermia during hemorrh
agic shock.