MULTICENTRIC RENAL ANGIOMYOLIPOMA ASSOCIATED WITH PULMONARY LYMPHANGIOLEIOMYOMATOSIS - CASE-REPORT, WITH HISTOLOGIC, IMMUNOHISTOCHEMICAL, AND DNA CONTENT ANALYSES

A 26-year-old pregnant woman presented with pulmonary lymphangioleiomy omatosis (LAM) and multicentric angiomyolipoma (AML) involving the lef t kidney and perirenal lymph nodes. In both tumors, smooth muscle cell s were the predominant component. Immunohistochemically, these cells s tained for vimentin, smooth muscle actin, desmin, and HMB-45. Estrogen receptors were weakly positive in LAM and negative in AML. Progestero ne receptors were negative for both lesions. DNA content analysis stud ies showed the renal AML to be diploid with a minor aneuploid componen t, the lymph node AML aneuploid, and the LAM diploid. The diagnostic a nd prognostic significance of hormonal studies and DNA content analysi s are discussed.