CONCURRENCE OF CYTOCHEMICAL AND IMMUNE PA TTERNS OF DIFFERENT CELLULAR LINEAGES IN CASES OF ACUTE-LEUKEMIA

Mixed, bilinear, biclonal and hybrid leukemias are synonymous, differi ng from biphenotypical ones. Mixed acute leukemia is defined by the co incidence of 1) two cytochemical markers of different lineage, or 2) o ne of them with more than one opposite immunological marker, or 3) mor e than one immunological marker opposite to another immunological line age. Seven cases of mixed acute leukemia are presented, two of which s howed posttreatment switching. It is concluded that mixed acute leukem ias are associated with a poor prognosis, and therapeutic criteria are defined.