Among the nonatherosclerotic vascular diseases leading to-ischemic com
plications in young adults, fibromuscular dysplasia (FMD) is relativel
y common. Manifestations of this abnormality most frequently occur sec
ondary to stenosis, aneurysm formation, or embolization of the renal o
r internal carotid arterial beds. Although 3 cases of external iliac a
rtery dissection (2 with confirmed FMD) have been reported, no reports
exist of isolated dissection of the common iliac artery in the absenc
e of a more proximal aortic entry point. Three otherwise healthy men w
ere diagnosed with acutely symptomatic isolated iliac artery dissectio
n (2 common iliac, 1 external iliac). Two patients required arterial b
ypass grafting for the relief of ischemia; histologic examination demo
nstrated FMD. The third patient had early findings on arteriography of
associated renal arterial FMD. Although a dissection of the common il
iac artery was confirmed in this patient on imaging studies as well as
arteriography, he manifested no ischemic symptoms or aneurysmal dilat
ion and is being managed nonoperatively. The diagnosis of arterial dis
section secondary to FMD should be strongly considered in the differen
tial diagnosis of young patients with signs and symptoms of lower extr
emity ischemia. Noninvasive diagnostic modalities (computerized tomogr
aphy [CT], magnetic resonance imaging [MRI], and duplex scans) will es
tablish the diagnosis, but arteriography remains essential to delineat
e the extent of involvement. The associated finding of FMD in other va
scular beds may help to confirm the diagnosis as well as contribute to
the future management of these patients.