REMISSION OF SCLEROMYXEDEMA FOLLOWING TREATMENT WITH EXTRACORPOREAL PHOTOPHERESIS

Scleromyxoedema, a disseminated papular and sclerotic variant of liche n myxoedematosus, is a rare disease with a chronic progressive course, and little tendency towards spontaneous remission, The treatment of s cleromyxoedema has been largely ineffective, Aggressive chemotherapeut ic agents have been used, often leading to therapy-related morbidity a nd mortality. We report a 41-year-old woman with. scleromyxoedema, ass ociated with a monoclonal gammopathy of IgG-kappa type, whose conditio n almost completely cleared with 12 monthly sessions of extracorporeal photopheresis, The patient had previously not responded to isotretino in, and chlorambucil with prednisolone.