CAVUM SEPTUM PELLUCIDUM IN SCHIZOPHRENIA - A MAGNETIC-RESONANCE-IMAGING STUDY

In order to determine if cavum septum pellucidum (CSP) is more prevale nt in schizophrenic patients, we studied 72 Japanese patients who fulf illed the DSM-III-R criteria for schizophrenia and 41 normal controls. Sagittal, 1 mm thick magnetic resonance imaging slices of the entire cranium were obtained using a gradient-echo pulse sequence, and corona l and axial images were reconstructed for assessment. A CSP was observ ed in 34 patients (47.2%) and in 16 controls (38.0%). Although the CSP appeared to be more prevalent in schizophrenic patients, this differe nce was not statistically significant. However, schizophrenic patients with a history of long-term institutionalization had a higher inciden ce of CSP compared with patients who had not been admitted to hospital for more than 3 years (68.2 vs 38.0%). These results suggest that the CSP may be a pathophysiology that characterizes schizophrenic patient s with poor prognoses.