INTERSPECIES SCALING - PREDICTING CLEARANCE OF ANTICANCER DRUGS IN HUMANS - A COMPARATIVE-STUDY OF 3 DIFFERENT APPROACHES USING BODY-WEIGHTOR BODY-SURFACE AREA

From this study it is proposed that the clearance of anti-cancer drugs may be best estimated if they follow the following trend: (i) that if the exponent of the allometric equation (clearance vs body weight) li es between 0.55-0.75 (0.75 was chosen after Kleiber's power rule (18)) , then a simple allometric equation can predict the clearance reasonab ly well; (ii) if the exponent of the allometric equation lies between 0.75 to approximately 0.90, clearance can be reasonably predicted usin g CL x MLP; and (iii) if the exponent of the allometric equation is gr eater than or equal to 0.90, the clearance can be predicted using the product of clearance and brain weight.