ASCORBATE PROMOTES LOW-DENSITY-LIPOPROTEIN OXIDATION IN THE PRESENCE OF FERRITIN

Authors
DAI LI WINYARD PG ZHANG Z BLAKE DR MORRIS CJ
Citation
Li. Dai et al., ASCORBATE PROMOTES LOW-DENSITY-LIPOPROTEIN OXIDATION IN THE PRESENCE OF FERRITIN, Biochimica et biophysica acta, L. Lipids and lipid metabolism, 1304(3), 1996, pp. 223-228
Citations number
34
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta, L. Lipids and lipid metabolism → ACNP
ISSN journal
00052760
Volume
1304
Issue
3
Year of publication
1996
Pages
223 - 228
Database
ISI
SICI code
0005-2760(1996)1304:3<223:APLOIT>2.0.ZU;2-R
Abstract
Whilst catalytic iron has been implicated in the development of athero sclerosis by initiating low density lipoprotein (LDL) oxidation, the s ource of such iron remains uncertain. Here, we show that LDL oxidation in the presence of ferritin was stimulated by ascorbate (15-60 mu M), whilst this effect was inhibited by the iron chelator desferrioxamine . Ascorbate also showed an antioxidant activity at high concentrations (125-250 mu M). Our results suggest that the combination of ascorbate with ferritin may supply free iron for LDL oxidation in vivo.