L. Avallone et al., RESEARCH ON HETEROCYCLIC-COMPOUNDS .35. SYNTHESIS OF 2-PHENYLIMIDAZO[1,2-A]-PYRAZINE-3-ACETATES, Monatshefte fuer Chemie, 127(8-9), 1996, pp. 947-953
Prompted by the remarkable pharmacological activity shown by the corre
sponding carboxylic acids and other analogues, a series of 2-phenylimi
dazo[1,2-a]pyrazine-3-acetic acids has been prepared. A multi-step met
hod similar to a synthetic procedure used to obtain Zolpidem, an imida
zo[1,2-a]pyridine with hypnotic properties has been developed.