COMPARISON OF HIGH-PERFORMANCE CAPILLARY ELECTROPHORESIS AND LIQUID-CHROMATOGRAPHY FOR THE DETERMINATION OF ACYCLOVIR AND GUANINE IN PHARMACEUTICALS AND URINE

Authors
ZHANG SS LIU HX CHEN Y YUAN ZB
Citation
Ss. Zhang et al., COMPARISON OF HIGH-PERFORMANCE CAPILLARY ELECTROPHORESIS AND LIQUID-CHROMATOGRAPHY FOR THE DETERMINATION OF ACYCLOVIR AND GUANINE IN PHARMACEUTICALS AND URINE, BMC. Biomedical chromatography, 10(5), 1996, pp. 256-257
Citations number
7
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy",Biology,"Biochemical Research Methods
Journal title
BMC. Biomedical chromatography → ACNP
ISSN journal
02693879
Volume
10
Issue
5
Year of publication
1996
Pages
256 - 257
Database
ISI
SICI code
0269-3879(1996)10:5<256:COHCEA>2.0.ZU;2-8
Abstract
High-performance capillary electrophoresis (HPCE) and high-performance liquid chromatography (HPLC) were developed and applied to the determ ination of acyclovir (ACV) and guanine (G) in pharmaceuticals. The com parison study showed that two methods gave comparable results in linea r range, recovery and reproducibility. HPCE was used for the determina tion of ACV and G in urine; the recovery was better than 81.3% and the RSD was less than 4.4%.