MOLECULAR-BASIS OF T-LYMPHOCYTE CD4 ANTIGEN FUNCTIONS

Authors
GAUBIN M AUTIERO M HOULGATTE R BASMACIOGULLARI S AUFFRAY C PIATIERTONNEAU D
Citation
M. Gaubin et al., MOLECULAR-BASIS OF T-LYMPHOCYTE CD4 ANTIGEN FUNCTIONS, European journal of clinical chemistry and clinical biochemistry, 34(9), 1996, pp. 723-728
Citations number
50
Categorie Soggetti
Biology,"Chemistry Medicinal
Journal title
European journal of clinical chemistry and clinical biochemistry → ACNP
ISSN journal
09394974
Volume
34
Issue
9
Year of publication
1996
Pages
723 - 728
Database
ISI
SICI code
0939-4974(1996)34:9<723:MOTCAF>2.0.ZU;2-P
Abstract
The T cell surface antigen CD4 plays a pivotal role in the MHC class I I-restricted response of specific T lymphocytes and serves as the majo r receptor of human immunodeficiency viruses (HIV). Recent studies hav e shown the high complexity of CD4 functions in physiological and path ological conditions. We report here a short review of recent developme nts in the field and discuss the structural features which regulate th e functions mediated by the CD4 coreceptor in mature T lymphocytes.