DOSE-DEPENDENT REVERSAL EFFECTS OF CAPSAICIN ON INTERLEUKIN-1-ALPHA PRODUCTION IS ASSOCIATED WITH THE METABOLISM OF ARACHIDONIC-ACID (LEUKOTRIENE B-4 AND PROSTAGLANDIN E(2)) AS WELL AS NITRIC-OXIDE PRODUCTION IN HUMAN-LEUKOCYTES
A. Panossian et al., DOSE-DEPENDENT REVERSAL EFFECTS OF CAPSAICIN ON INTERLEUKIN-1-ALPHA PRODUCTION IS ASSOCIATED WITH THE METABOLISM OF ARACHIDONIC-ACID (LEUKOTRIENE B-4 AND PROSTAGLANDIN E(2)) AS WELL AS NITRIC-OXIDE PRODUCTION IN HUMAN-LEUKOCYTES, Phytomedicine, 3(2), 1996, pp. 169-174
This study attempts to determine the dose-dependent effects of capsaic
in, the pungent principle of red hot pepper, on the early intracellula
r events after the binding of capsaicin to immunocompetent cells. It s
hows that capsaicin stimulates the release of AA as well as PGE(2) and
LTB(4). At high doses capsaicin activates NO-production in human lymp
hocytes. At low concentrations (10(-8) to 10(-5) M) it increases the I
L-1 alpha-production from human lymphocytes, whereas at concentrations
of 10(-4) M this production is inhibited. The possible mechanisms of
action of the various pharmacological effects of capsaicin are discuss
ed.