SUCCESSFUL ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR EARLY RELAPSE AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN 2 CASES OF AGGRESSIVE HIGH-GRADE NON-HODGKINS-LYMPHOMA

Authors
MOREAU P MECHINAUD F MAHE B LETORTOREC S RAPP MJ MAISONNEUVE H HAROUSSEAU JL MILPIED N
Citation
P. Moreau et al., SUCCESSFUL ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR EARLY RELAPSE AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN 2 CASES OF AGGRESSIVE HIGH-GRADE NON-HODGKINS-LYMPHOMA, Bone marrow transplantation, 18(3), 1996, pp. 665-667
Citations number
19
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
18
Issue
3
Year of publication
1996
Pages
665 - 667
Database
ISI
SICI code
0268-3369(1996)18:3<665:SABTFE>2.0.ZU;2-C
Abstract
Two patients with high-grade disseminated non-Hodgkin's lymphoma relap sed 3 and 7 months respectively after high-dose chemotherapy and autol ogous BMT performed in first complete remission, Both patients had an HLA-identical sibling and received an allogeneic BMT 5 and 10 months a fter autologous BMT, after conditioning with fractionated 12 Gy total body irradiation plus cyclophosphamide. They both are alive and well, with a Karnofsky score of 100%, 15 and 27 months after allogeneic BMT. For selected patients with HLA-identical siblings and good performanc e status who relapse after autologous transplantation for high-grade n on-Hodgkin's lymphoma, allogeneic BMT may be an option.