A PRECLINICAL ASSESSMENT OF THE EFFECT OF LIPO-PGE(1) ON THROMBUS FORMATION AND THROMBUS DISAGGREGATION

Prostaglandin E(1) incorporated in lipid microspheres (lipo-PGE(1)) wa s evaluated as an inhibitor of ADP-induced thrombus growth and as a th rombus disaggregating agent following vascular damage in the microcirc ulation of the hamster cheek pouch. The lipo-preparation was shown to be significantly more active and longer acting than PGE(1) as an inhib itor of ADP-induced thrombus formation. In the vascular damage model, Lipo-PGE(1) was very efficacious as a thrombus-disaggregating agent an d was significantly more effective when administered after, rather tha n before, vascular damage and thrombus induction. The data suggested t hat the lipo-preparation might be targeted to the site of damage.