LIPID MICROSPHERE PREPARATION OF A PROSTACYCLIN ANALOG

Authors
KUROZUMI S ARAKI H TANABE H KIYOKI M
Citation
S. Kurozumi et al., LIPID MICROSPHERE PREPARATION OF A PROSTACYCLIN ANALOG, Advanced drug delivery reviews, 20(2-3), 1996, pp. 181-187
Citations number
32
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Advanced drug delivery reviews → ACNP
ISSN journal
0169409X
Volume
20
Issue
2-3
Year of publication
1996
Pages
181 - 187
Database
ISI
SICI code
0169-409X(1996)20:2-3<181:LMPOAP>2.0.ZU;2-6
Abstract
Prostacyclin is one of the most potent vasoactive autacoids, and is no w clinically used as an anti-platelet agent, but with limited indicati ons due to its chemical instability, as well as side effects. A chemic ally stable prostacyclin derivative (Clinprost) of isocarbacyclin in a lipid microsphere formulation (TTC-909) was found to be successful wh en applied in the treatment of various thrombotic diseases, as it disp enses with problems inherent to naturally occurring prostacyclin.