Hepatic C virus (HCV) has been recognized increasingly as a major publ
ic health crisis in the United States, causing infection in an estimat
ed 3.5 million people and resulting in 8000 to 10,000 deaths annually
from liver-related complications. This article focuses on the clinical
aspects and diagnosis of hepatitis C, the importance of excluding oth
er chronic liver diseases, and the current basis and strategy for trea
tment of HCV infection with interferon. ideally, it will help primary
care providers with the task of evaluating, diagnosing, teaching, and
caring for patients with this chronic, potentially debilitating, and l
ethal disease.