Ih. Hall et al., THE ANTIINFLAMMATORY ACTIVITY OF METAL-COMPLEXES OF HETEROCYCLIC THIOSEMICARBAZONES, 2-SUBSTITUTED PYRIDINE N-OXIDES AND 2-PYRIDYLTHIOUREAS, Applied organometallic chemistry, 10(7), 1996, pp. 485-493
The thiosemicarbazones and their related metal complexes were shown to
be potent anti-inflammatory agents in rodents at 8 mg kg(-1). They we
re effective in blocking induced edema and endotoxic shock while block
ing both local and central pain processes, The ability of the agents t
o function as anti-inflammatory agents is multifold, First, Tumor Necr
osis Factor-alpha (TNF alpha) and Interleukin-l (IL-1) release was mar
kedly reduced by the agents, Second, high-affinity receptor binding on
fibroblasts of TNF alpha and IL-1 was significantly inhibited, Third,
cellular events, e.g. lysosomal enzymes of specific cells, such as ma
crophages, were inhibited and prostaglandin cyclo-oxygenase and leukot
riene 5'-lipoxygenase enzymic synthetic rates were significantly reduc
ed, which should cause an overall reduction of the inflammatory proces
s.