THE ANTIINFLAMMATORY ACTIVITY OF METAL-COMPLEXES OF HETEROCYCLIC THIOSEMICARBAZONES, 2-SUBSTITUTED PYRIDINE N-OXIDES AND 2-PYRIDYLTHIOUREAS

The thiosemicarbazones and their related metal complexes were shown to be potent anti-inflammatory agents in rodents at 8 mg kg(-1). They we re effective in blocking induced edema and endotoxic shock while block ing both local and central pain processes, The ability of the agents t o function as anti-inflammatory agents is multifold, First, Tumor Necr osis Factor-alpha (TNF alpha) and Interleukin-l (IL-1) release was mar kedly reduced by the agents, Second, high-affinity receptor binding on fibroblasts of TNF alpha and IL-1 was significantly inhibited, Third, cellular events, e.g. lysosomal enzymes of specific cells, such as ma crophages, were inhibited and prostaglandin cyclo-oxygenase and leukot riene 5'-lipoxygenase enzymic synthetic rates were significantly reduc ed, which should cause an overall reduction of the inflammatory proces s.