NITRIC-OXIDE SYNTHASE IS CONCENTRATED AT THE SKELETAL-MUSCLE END-PLATE

Authors
KUSNER LL KAMINSKI HJ
Citation
Ll. Kusner et Hj. Kaminski, NITRIC-OXIDE SYNTHASE IS CONCENTRATED AT THE SKELETAL-MUSCLE END-PLATE, Brain research, 730(1-2), 1996, pp. 238-242
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
730
Issue
1-2
Year of publication
1996
Pages
238 - 242
Database
ISI
SICI code
0006-8993(1996)730:1-2<238:NSICAT>2.0.ZU;2-3
Abstract
NO performs a wide array of cell signaling functions. Neuronal NO synt hase (nNOS) immunoreactivity and nicotinamide adenine dinucleotide pho sphate diaphorase (NDP) activity, a marker of nNOS, were concentrated at adult rat neuromuscular junctions and persisted in denervated muscl e indicating the localization of the enzyme to the postsynaptic surfac e. The concentration of nNOS at the muscle endplate suggests NO could serve as a messenger pre- and postsynapticly.