DENDRIMER-SUPPORTED COMBINATORIAL CHEMISTRY

A new methodology for the construction of combinatorial libraries is d escribed. The approach, termed dendrimer-supported combinatorial chemi stry (DCC), centers on the use of dendrimers as soluble supports, Sali ent features of DCC include solution phase chemistry, homogeneous puri fication, routine characterization of intermediates, and high support loadings. To demonstrate the feasibility of DCC, single compounds and a small combinatorial library were prepared via the Fischer indole syn thesis. Excellent product yields and purities were obtained, and dendr imer-protected intermediates could be routinely analyzed by H-1 and C- 13 NMR and by mass spectrometry. The results indicate that DCC is a ge neral and efficient strategy for the generation of combinatorial libra ries.