INFLUENCE OF ASSOCIATED VIRAL-HEPATITIS STATUS ON RECURRENCE OF HEPATOCELLULAR-CARCINOMA AFTER HEPATECTOMY

The purpose of this study was to investigate the relation between the recurrence of hepatocellular carcinoma (HCC) and the histologic status of underlying chronic liver disease from a viewpoint of multicentric hepatocarcinogenesis. Sixty-eight patients who underwent curative rese ction of HCC and have been followed for more than 2 years are reported . Based on the microscopic findings of the noncancerous part of the li ver, the patients were divided into normal liver (N, n = 2), chronic p ersistent hepatitis (CPH, n = 6), chronic aggressive hepatitis (CAH, n = 31), and liver cirrhosis (LC, n = 29) according to a classification by the European Association for the Study of the Liver. Background da ta for the groups showed no significant differences. Recurrence was ob served in none of the patients in the N and CPH groups, 26 (83.9%) of the patients in the CAH group, and 12 (41.4%) of the patients in the L C group. The cumulative disease-free survival rate of the CAH group wa s significantly lower than that of the CPH group (p < 0.05) and LC gro up (p < 0.01). This study revealed that the histologic status of the u nderlying chronic liver disease influenced the recurrence rate in pati ents with HCC. CAH was considered to be a risk factor for recurrence a fter resection of HCC.