TRIPPING THE SWITCH FANTASTIC - HOW A PROTEIN-KINASE CASCADE CAN CONVERT GRADED INPUTS INTO SWITCH-LIKE OUTPUTS

Authors
FERRELL JE
Citation
Je. Ferrell, TRIPPING THE SWITCH FANTASTIC - HOW A PROTEIN-KINASE CASCADE CAN CONVERT GRADED INPUTS INTO SWITCH-LIKE OUTPUTS, Trends in biochemical sciences, 21(12), 1996, pp. 460-466
Citations number
32
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
21
Issue
12
Year of publication
1996
Pages
460 - 466
Database
ISI
SICI code
0968-0004(1996)21:12<460:TTSF-H>2.0.ZU;2-Z
Abstract
Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like output s. The cascade could therefore filter out noise (signals of insufficie nt magnitude or duration) and still respond decisively to supra-thresh old stimuli. Here, we explore the biochemical mechanisms likely to be at the root of this behavior.