PREPARATION, DISSOLUTION AND CHARACTERIZATION OF ALBENDAZOLE SOLID DISPERSIONS

In this study, solid dispersion systems of the sparingly water soluble drug, albendazole (ABZ), were mixed with varying concentrations of po lyvinylpyrrolidone (PVP K 12) in an attempt to improve the solubility and dissolution rate of ABZ. Physical characteristics were investigate d by Powder X-ray diffraction. As expected, the-albendazole dissolutio n rate, expressed as the dissolution efficiency, and also the solubili ty coefficient were increased when albendazole was mixed with PVP. An increase in the concentration of the polymer in the solid dispersion p roduced an increase in both parameters. The powder X-ray diffraction p atterns showed that the solid dispersion presented an amorphous form o f albendazole in this coprecipitate system.