GENERALIZED ACANTHOSIS NIGRICANS WITH VITILIGO

We report on a 19-year-old woman with generalised acanthosis nigricans of the inherited type and concomitant vitiligo. Cutaneous velvety thi ckening of the skin with intensification of skin markings and progress ive development of hyperpigmented papillomatous, verrucoid lesions in the body folds started to develop in early childhood. These hyperpigme ntations were continuously replaced by a progressive vitiligo, finally leaving most of the acanthosis nigricans lesions completely depigment ed. Generalised, pachyderma-like acanthosis nigricans with concomitant vitiligo is an association which to the best of our knowledge has not yet been described.