IDENTIFICATION, SEQUENCING, AND ENZYMATIC-ACTIVITY OF THE ERYTHROSE-4-PHOSPHATE DEHYDROGENASE GENE OF VIBRIO-CHOLERAE

Authors
CARROLL PA ZHAO GS BOYKO SA WINKLER ME CALDERWOOD SB
Citation
Pa. Carroll et al., IDENTIFICATION, SEQUENCING, AND ENZYMATIC-ACTIVITY OF THE ERYTHROSE-4-PHOSPHATE DEHYDROGENASE GENE OF VIBRIO-CHOLERAE, Journal of bacteriology, 179(1), 1997, pp. 293-296
Citations number
20
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology → ACNP
ISSN journal
00219193
Volume
179
Issue
1
Year of publication
1997
Pages
293 - 296
Database
ISI
SICI code
0021-9193(1997)179:1<293:ISAEOT>2.0.ZU;2-P
Abstract
We have identified a gene in vibrio choler ne (epd) which encodes an e rythrose-4-phosphate dehydrogenase activity and is located immediately downstream of an iron-regulated virulence gene, irgA, and immediately upstream of a gene encoding phosphoglycerate kinase (pgk). Expression of epd in V. cholerae is not regulated by iron, nor is it required fo r virulence in an infant mouse model.