COMPARATIVE GENOTOXICITY OF 6 SALICYLIC-ACID DERIVATIVES IN BONE-MARROW CELLS OF MICE

In vivo sister chromatid exchange (SCE) and chromosome aberrations (CA ) were carried out for six salicylic acid derivatives in bone marrow c ells of mice. Six salicylic acid derivatives, namely acetyl salicylic acid (aspirin); salicylic acid, salicylamide, sodium salicylate, diflu nisal and niclosamide, were used for these experiments. Drugs were adm inistered both intraperitoneally (i.p.) and orally by gavage. Out of t hese six salicylic acid derivatives tested, only diflunisal and niclos amide showed genotoxicity as measured by both SCE and CA assays. Acety l salicylic acid and sodium salicylate showed weak genotoxicity as mea sured by SCE and CA, respectively, only at the highest dose tested.