Lj. Mao et Ry. Chen, STUDIES ON THE CONDENSATION OF HIGHLY HINDERED ALPHA-AMINO METHYLPHOSPHONATES WITH BETA-TRIPHENYLGERMANYL PROPIONIC-ACID, Phosphorus, sulfur and silicon and the related elements, 111(1-4), 1996, pp. 798-798
The condensation reaction of highly hindered a-amino methylphosphonate
s with beta-triphenylgermanyl propionic acid was studied. The two nove
l series 4-5 were designed and synthesized in good yields. Preliminary
bioassays showed that the compounds 4-5 exhibited significant antitum
or activities both in vivo and in vitro.