R. Chidambaram et al., SEEKING HYDROGEN-BONDS - WITH AND WITHOUT NEUTRON-DIFFRACTION, Proceedings of the Indian Academy of Sciences. Chemical sciences, 106(6), 1994, pp. 1349-1361
The hydrogen-bond interaction can be studied using a variety of spectr
oscopic and crystallographic techniques, as well as theoretical studie
s based on quantum chemical principles, semi-empirical procedures, and
statistical interpretations. A degree of specificity, along with flex
ibility, provides H-bonded systems with a variety of unusual and inter
esting physical, chemical and biological properties. Neutron diffracti
on is the method of choice For obtaining high-precision data on hydrog
en-atom positions and hydrogen-bond stereochemistry in crystals. Neutr
on inelastic scattering can provide information on the dynamics of H-b
onded systems. High-precision neutron diffraction studies on a variety
of crystal hydrates, amino acids and small peptides, development of s
emi-empirical potential functions for bent-hydrogen bonds, and statist
ical analysis of H-bond populations associated with various donor and
acceptor groups are some of the investigations on hydrogen bonding, ca
rried out at Trombay during the past three decades.