To determine whether differences in the retinohypothalamic tract (RHT)
were related specifically to albinism, we analyzed the distribution a
nd trajectory of this pathway in congenic F344-c/+ albino and pigmente
d rats using the inactive subunit of cholera toxin conjugated to horse
radish peroxidase as an anterograde tracer. We found that the overall
volume of the tract in the albino rats was greater than in the pigment
ed rats (P <0.05). We also noted shape differences.