EFFECT OF IOMEPROL ON RENAL-FUNCTION IMMEDIATELY AFTER ABDOMINAL ANGIOGRAPHY

Purpose: To investigate the acute rehal effects of 2 osmolality levels of iomeprol in a double-blind, randomized, parallel-group study. Mate rial and Methods: Ten patients received iomeprol 300 mg I/ml, and a fu rther 10 received iomeprol 400 mg I/ml intraarterially at routine abdo minal angiography. The mean volume of contrast medium administered was 227.3+/-59.3 ml in the iomeprol 300 group and 221.5+/-30.9 ml in the iomeprol 400 group. Results: The urinary minute volume increased immed iately after angiography, but tended to return to baseline 120 min aft er the examination. No significant decrease in creatinine clearance oc curred; however, the fraction excretion of sodium increased immediatel y after angiography. The lysosomal enzyme N-acetyl-beta-glucosaminidas e and the proximal tubular brush border enzyme gamma-glutamyl transfer ase increased up to 120 min after the procedure. Free water clearance was negative during each study period. No statistical differences in a ny parameter were evident between these 2 groups. Conclusion: These re sults suggest that osmotic diuresis and its acute effect on proximal t ubular function are induced by the administration of iomeprol, but tha t these changes are reversible.