NONSYNDROMIC X-LINKED MENTAL-RETARDATION - REVIEW AND MAPPING OF MRX29 TO XP21

Authors
HANE B SCHROER RJ ARENA JF LUBS HA SCHWARTZ CE STEVENSON RE
Citation
B. Hane et al., NONSYNDROMIC X-LINKED MENTAL-RETARDATION - REVIEW AND MAPPING OF MRX29 TO XP21, Clinical genetics, 50(4), 1996, pp. 176-183
Citations number
49
Categorie Soggetti
Genetics & Heredity
Journal title
Clinical genetics → ACNP
ISSN journal
00099163
Volume
50
Issue
4
Year of publication
1996
Pages
176 - 183
Database
ISI
SICI code
0009-9163(1996)50:4<176:NXM-RA>2.0.ZU;2-M
Abstract
The gene responsible for nonsyndromic mental retardation in a family w ith 7 affected males has been localized to Xp21. The maximal two-point lod score was 3.31 for tight linkage to marker DXS1202 in Xp21.3-p22. 3 with crossovers between the 3' portion of the DMD gene (DXS1234) pro ximally and locus DXS989 distally. The XLMR gene in this family has be en assigned the designation MRX29. The localization overlaps with at l east six other MRX entities Linked to the distal short arm of the X ch romosome.