Aims: it is now recommended that cord blood acid-base measurement is p
erformed routinely at time of delivery in the UK as a measure of fetal
response to labour, However, there remains some uncertainty about the
value of this procedure, In this paper our experience of cord blood a
nalysis is described and the literature is reviewed to: (1) provide an
overview of the physiological basis of cord blood acid-base assessmen
t; (2) describe the appropriate methodology and identify issues which
have contributed to confusion and undermined the value of cord blood s
ampling; and (3) address the practical issues of cord blood sampling.
Conclusions: cord blood acid-base measurement has a sound physiologica
l basis, It provides objective information which is a useful adjunct t
o subjective methods of newborn assessment, enables babies at risk of
neonatal morbidity to be identified, can be helpful in litigation case
s and is a prerequisite for clinical audit, However, to be of benefit
the information must be correct and correctly interpreted.