SYNTHESIS OF STEROIDAL EXTRANUCLEO 1,3,4-OXADIAZOLES

Authors
SIDDIQUI AU SATYANARAYANA Y AHMED I SIDDIQUI AH
Citation
Au. Siddiqui et al., SYNTHESIS OF STEROIDAL EXTRANUCLEO 1,3,4-OXADIAZOLES, Journal of heterocyclic chemistry, 33(4), 1996, pp. 1385-1387
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
33
Issue
4
Year of publication
1996
Pages
1385 - 1387
Database
ISI
SICI code
0022-152X(1996)33:4<1385:SOSE1>2.0.ZU;2-S
Abstract
Cholest-5en-3 beta-ol 1,3,3-ethylenedioxy-androst-4-en-17 beta-ol 2 an d 17,17-ethylenedioxy-1,3,5(10)-estratrien-3 beta-ol 3 were converted into ethyl ester 1a, 2a and 3a by reaction with ethyl chloroacetate in the presence of potassium. The ethyl esters 1a, 2a and 3a on reaction with hydrazine gave hydrazides 1b, 2b and 3b, which on reaction with cyanogen bromide afforded 1,3,4-oxadiazoles 1c, 2c and 3c.