THE MECHANISM OF GA-67 LOCALIZATION IN MALIGNANT DISEASE

After almost two decades of research, evidence suggests that transferr in receptors are rate-limiting in Ga-67 uptake. Ga-67 imaging is an in vivo detector of transferrin receptors and an indicator of tumor cell proliferation. Moreover, Ga-67 can be incorporated into tumor cells b y a transferrin receptor-independent process. This pathway could be im portant in patients with saturated transferrin. Data that appear to su pport the concept that transferrin receptor-independent transporters a re rate-limiting can be resolved by considering the presence of the ga llate ion, [Ga-67 (OH)(4)](-).