USE OF HEPTAKIS(2,6-DI-O-METHYL)-BETA-CYCLODEXTRIN IN ONLINE CAPILLARY ZONE ELECTROPHORESIS MASS-SPECTROMETRY FOR THE CHIRAL SEPARATION OF ROPIVACAINE

The on-line coupling of chiral capillary zone electrophoresis (CZE) wi th mass spectrometry (MS) is described for the chiral separation of th e basic drug ropivacaine using a coupled capillary system with the pos sibility of voltage switching. With this set-up, the introduction into the MS of the chiral selector heptakis(2,6-di-O-methyl)-beta-cyclodex trin (DM-beta-CD) that has a detrimental effect on MS performance is a voided. In combination with MS detection, this coupled capillary set-u p can be regarded as universally applicable for all CZE separations wh ere the use of buffer additives that have negative influence on the MS is necessary.