REFERENCE INTERVALS OF CD3, CD4, CD8, CD4 CD8, AND ABSOLUTE CD4 VALUES IN ASIAN AND NON-ASIAN POPULATIONS/

A study to determine reference intervals in normal Asian and non-Asian populations for CD3 (T cells), CD4 (T helper/inducer cells), CD8 (T s uppressor/cytotoxic cells), and for the CD4/CD8 ratio and absolute CD4 lymphocyte count was performed, Coulter Clone/Cytostat reagents were used. The samples were lysed using the Coulter Q-Prep and analyzed on the Coulter Profile II flow cytometer, The Asian population appeared t o have a lower mean percentage of CD3 and CD4 cells, a lower CD4/CD8 r atio, and lower absolute CD4 lymphocytes. These findings indicate that race should be a consideration in determining reference intervals for immunophenotyping far CD3, CD4, and CD8. (C) 1996 Wiley-Liss, Inc.