T. Staroske et al., SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF CARDENOLIDES SUBSTITUTED AT THE BUTENOLIDE PART, Tetrahedron, 52(39), 1996, pp. 12723-12744
Deprotonation of the digitoxigenin lactone moiety with NaH in N-methyl
pyrrolidone yields an enolate that reacts at the 21- or 22-position de
pending on the electrophile. Lactone substituted derivatives of digito
xigenin have been prepared and their inhibition of the cardiac Na+ pum
p and the inotropic effect of some of the compounds have been studied.
Structure-activity relationships are discussed in terms of the Holtje
-Anzali model. Copyright (C) 1996 Elsevier Science Ltd