SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF CARDENOLIDES SUBSTITUTED AT THE BUTENOLIDE PART

Citation
T. Staroske et al., SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF CARDENOLIDES SUBSTITUTED AT THE BUTENOLIDE PART, Tetrahedron, 52(39), 1996, pp. 12723-12744
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00404020
Volume
52
Issue
39
Year of publication
1996
Pages
12723 - 12744
Database
ISI
SICI code
0040-4020(1996)52:39<12723:SAPPOC>2.0.ZU;2-S
Abstract
Deprotonation of the digitoxigenin lactone moiety with NaH in N-methyl pyrrolidone yields an enolate that reacts at the 21- or 22-position de pending on the electrophile. Lactone substituted derivatives of digito xigenin have been prepared and their inhibition of the cardiac Na+ pum p and the inotropic effect of some of the compounds have been studied. Structure-activity relationships are discussed in terms of the Holtje -Anzali model. Copyright (C) 1996 Elsevier Science Ltd