K. Kontturi et L. Murtomaki, MECHANISTIC MODEL FOR TRANSDERMAL TRANSPORT INCLUDING IONTOPHORESIS, Journal of controlled release, 41(3), 1996, pp. 177-185
A mechanistic model is presented to describe the transdermal transfer
of drugs. In the model, flux is divided into the contributions through
the lipid matrix and through aqueous pores. During iontophoresis, onl
y flux through aqueous pores is enhanced because the relative permitti
vity of the lipid matrix is too low to allow the existence of free ion
s which could work as current carriers. The transfer through the lipid
matrix is assumed to take place in three steps: (i) partition at the
skin/reservoir interface; (ii) diffusion through the lipid matrix; (ii
i) desorption at the stratum corneum/epidermis interface. Simulations
to the present model agree with experimental results in the literature
.