LACK OF LINKAGE BETWEEN IDIOPATHIC GENERALIZED EPILEPSIES AND THE GENE ENCODING THE NEURAL CELL-ADHESION MOLECULE

Citation
T. Sander et al., LACK OF LINKAGE BETWEEN IDIOPATHIC GENERALIZED EPILEPSIES AND THE GENE ENCODING THE NEURAL CELL-ADHESION MOLECULE, Epilepsy research, 25(2), 1996, pp. 139-145
Citations number
40
Categorie Soggetti
Clinical Neurology
Journal title
ISSN journal
09201211
Volume
25
Issue
2
Year of publication
1996
Pages
139 - 145
Database
ISI
SICI code
0920-1211(1996)25:2<139:LOLBIG>2.0.ZU;2-N
Abstract
Hereditary factors play a major role in the etiology of idiopathic gen eralized epilepsies (IGEs). The frequent neuropathological occurrence of microdysgeneses in the brain of IGE patients implies that genes reg ulating neural migration and cell adhesion might be involved in epilep togenesis of age-related generalized seizures, Our present linkage stu dy tested the hypothesis that DNA sequence variants associated with th e gene encoding the neural cell adhesion molecule (NCAM) confer geneti c susceptibility to IGE traits in 57 families ascertained through pati ents with either juvenile myoclonic epilepsy, juvenile or childhood ab sence epilepsy. Our consistently negative results provide evidence aga inst a common major effect of NCAM gene variants to the expression of IGEs with age-related onset from childhood to adolescence.