One hundred and forty-one women, aged 40-60 years, recruited from the
community were assessed with an initial interview, plus four interview
s at intervals of 1 week and blood samples. The objective was to inves
tigate the determinants of sexuality and well-being in this sample. Me
asures included interview ratings of sexual function, Frenken Sexual E
xperience Scales and the Multiple Affect Adjective Check List. Determi
nants evaluated, using multiple regression analysis, included age, men
opausal status, BMI, smoking, ovarian steroids and adrenal androgens.
None of the hormonal parameters significantly predicted measures of se
xuality; the most important predictors were other aspects of the sexua
l relationship, sexual attitudes and measures of well-being. The best
predictor of both well-being and depression was tiredness. The only ho
rmone positively related to well-being was dehydroepiandrosterone (DHE
A).